CLPP

Across TCGA pan-cancer cohorts, CLPP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLPP data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CLPP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLPP expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where CLPP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.361	0.752	<.001	41	view →
HNSC	DFS	Quartile	IV	0.510	0.865	.009	20	view →
LSCC	OS	Quartile	All	1.000	0.890	.029	8	view →
PDAC	DFS	Quartile	II,III,IV	0.674	0.335	.010	7	view →
LUAD	DFS	Median	II,III,IV	1.000	0.819	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLPP–CCRCC (DFS)

Open the CCRCC breakdown →