CLPP

Across TCGA pan-cancer cohorts, CLPP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CLPP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CLPP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLPP is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where CLPP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLPP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.277	<.001	12	view →
KIRC	Male	III,IV	+0.492	<.001	11	view →
HNSC	Male	IV	+0.607	<.001	8	view →
BLCA	All	All	+0.548	<.001	8	view →
LIHC	All	II,III,IV	+0.539	<.001	7	view →
STAD	All	II,III,IV	+0.493	.001	7	view →
KICH	Female	All	−0.701	<.001	6	view →
BRCA	All	III,IV	+0.638	<.001	6	view →
LUSC	All	II,III,IV	+0.633	<.001	6	view →
CHOL	All	All	+0.941	<.001	3	view →
READ	All	All	+0.623	.013	2	view →
ESCA	All	All	+0.888	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CLPP–COAD

Open the COAD breakdown →