CLPP

Across TCGA patient cohorts, CLPP RNA expression is significantly associated with the protein abundance of many other proteins, with 13,228 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLPP-associated proteins across cancer lineages are RRM1, KHSRP, and RAVER1. Each is linked with CLPP in more than 5 cancer types. Because this analysis shows association rather than direction, both CLPP-to-partner and partner-to-CLPP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLPP versus RRM1 in OV, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPP→partner) and Y-score (partner→CLPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RRM1 →	+0.419	+0.436	.001	.008	3	6
GBM	KHSRP →	+0.379	+0.434	<.001	<.001	3	6
LSCC	RAVER1 →	+0.305	+0.569	<.001	<.001	3	5
LSCC	CHAF1A_S141 →	+0.866	+0.463	<.001	<.001	3	5
GBM	CHAF1B →	+0.533	+0.326	<.001	<.001	3	5
LUAD	DNMT1_S714 →	+0.688	+0.406	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,228 associations by consensus.

CLPP vs RRM1 — OV

Explore this scatter interactively →