CLPP

Across TCGA patient cohorts, CLPP protein abundance is significantly associated with the RNA expression of many other genes, with 17,530 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CLPP-associated genes across cancer lineages are MFAP4, LONP1, and TIMP3. Each is linked with CLPP in more than 5 cancer types. Because this analysis shows association rather than direction, both CLPP-to-partner and partner-to-CLPP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLPP versus MFAP4 in BRCA, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPP→partner) and Y-score (partner→CLPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MFAP4 →	-1.484	-0.334	<.001	<.001	3	6
UCEC	LONP1 →	+0.877	+0.249	<.001	<.001	3	6
LSCC	TIMP3 →	-1.323	-0.380	<.001	<.001	3	5
BRCA	PLPP7 →	-0.360	-0.261	<.001	<.001	3	5
BRCA	EBF1 →	-0.795	-0.271	<.001	<.001	3	5
LSCC	DLC1 →	-0.907	-0.354	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,530 associations by consensus.

CLPP vs MFAP4 — BRCA

Explore this scatter interactively →