CLPP

Across TCGA cell cohorts, CLPP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,132 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLPP-associated GO terms across cancer lineages are Energy coupled proton transmembrane transport, against electrochemical gradient, Electron transport coupled proton transport, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with CLPP in more than 15 cancer types. Because this analysis shows association rather than direction, both CLPP-to-partner and partner-to-CLPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy coupled proton transmembrane transport, against electrochemical gradient grouped by CLPP-low versus CLPP-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPP→partner) and Y-score (partner→CLPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.102	+0.950	<.001	<.001	3	16
PANCREAS	Electron transport coupled proton transport →	+0.102	+0.950	<.001	<.001	3	16
BLOOD_Lymphoma	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.137	+1.162	<.001	<.001	3	14
BONE	Positive regulation of protein localization to chromatin →	+0.165	+1.076	<.001	<.001	3	14
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.150	+0.645	<.001	<.001	3	13
BONE	Cytoplasm protein quality control →	+0.122	+0.681	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,132 associations by consensus.

Energy coupled proton transmembrane transport, against electrochemical gradient by CLPP expression — PANCREAS

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