CLN6

Across TCGA cell cohorts, CLN6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,750 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLN6-associated GO terms across cancer lineages are DNA replication proofreading, DNA-templated DNA replication maintenance of fidelity, and Positive regulation of nuclear cell cycle DNA replication. Each is linked with CLN6 in more than 15 cancer types. Because this analysis shows association rather than direction, both CLN6-to-partner and partner-to-CLN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by CLN6-low versus CLN6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN6→partner) and Y-score (partner→CLN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication proofreading →	+0.190	+0.959	<.001	<.001	3	16
PANCREAS	DNA-templated DNA replication maintenance of fidelity →	+0.100	+1.449	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of nuclear cell cycle DNA replication →	+0.160	+1.210	<.001	.001	3	15
BONE	DNA replication checkpoint signaling →	+0.231	+1.352	.002	.002	3	15
BONE	Positive regulation of DNA-templated DNA replication →	+0.132	+1.124	<.001	.001	3	14
BONE	DNA integrity checkpoint signaling →	+0.103	+1.248	.009	.007	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,750 associations by consensus.

DNA replication proofreading by CLN6 expression — BONE

Explore this box plot interactively →