CLN6

Across TCGA pan-cancer cohorts, CLN6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CLN6 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CLN6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLN6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

ACC, UVM, and KICH are the cancer types where CLN6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.521	0.785	<.001	132	view →
UVM	OS	Quartile	All	0.406	0.913	<.001	76	view →
KICH	OS	Quartile	II,III,IV	0.256	0.931	<.001	70	view →
KIRC	DFS	Tertile	All	0.717	0.503	<.001	68	view →
LGG	DFS	Median	All	0.660	0.809	<.001	44	view →
SKCM	OS	Median	II,III,IV	0.214	0.404	<.001	42	view →
LIHC	DFS	Quartile	All	0.411	0.594	.002	31	view →
UCS	DFS	Tertile	IV	0.422	0.936	.024	30	view →
LUAD	OS	Tertile	All	0.551	0.745	.007	25	view →
MESO	OS	Median	All	0.295	0.477	.005	23	view →
UCEC	DFS	Quartile	III,IV	0.688	0.309	.010	22	view →
COAD	DFS	Quartile	IV	0.148	0.738	.007	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CLN6–ACC (DFS)

Open the ACC breakdown →