CLN6

Across TCGA cell cohorts, CLN6 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLN6-associated genes across cancer lineages are GPR101, CELA3B, and OR52K1. Each is linked with CLN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN6-to-partner and partner-to-CLN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by CLN6-low versus CLN6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN6→partner) and Y-score (partner→CLN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPR101 →	+0.119	+3.551	<.001	.009	3	2
SKIN	CELA3B →	+0.031	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	OR52K1 →	+0.013	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	SPATS1 →	+0.774	+5.129	<.001	<.001	3	1
BLOOD_Lymphoma	CLEC19A →	+0.070	+3.925	.004	.005	3	1
LARGE_INTESTINE	MDGA2 →	+0.112	+3.854	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

GPR101 by CLN6 expression — BLOOD_Leukemia

Explore this box plot interactively →