CLMP

Across TCGA cell cohorts, CLMP mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLMP-associated genes across cancer lineages are OPN4, MSGN1, and OR2B2. Each is linked with CLMP in more than 1 cancer types. Because this analysis shows association rather than direction, both CLMP-to-partner and partner-to-CLMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN4 grouped by CLMP-low versus CLMP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLMP→partner) and Y-score (partner→CLMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OPN4 →	+0.023	+3.930	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR2B2 →	+0.036	+4.347	<.001	.001	3	1
LARGE_INTESTINE	C12orf40 →	+0.013	+3.684	<.001	.006	3	1
LARGE_INTESTINE	C14orf180 →	+0.219	+4.155	<.001	.003	3	1
LARGE_INTESTINE	RNF212B →	+0.146	+3.678	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OPN4 by CLMP expression — LARGE_INTESTINE

Explore this box plot interactively →