CLK2

Across TCGA patient cohorts, CLK2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,848 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLK2-associated genes across cancer lineages are SPAG1, JCHAIN, and LOH12CR2. Each is linked with CLK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLK2-to-partner and partner-to-CLK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLK2 versus SPAG1 in BRCA, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK2→partner) and Y-score (partner→CLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPAG1 →	-0.936	-0.371	<.001	.002	3	3
OV	JCHAIN →	-2.522	-0.421	.003	.006	3	3
OV	LOH12CR2 →	+0.826	+0.500	.001	<.001	3	3
LUAD	RPS26P56 →	+0.580	+0.240	.001	.004	3	3
OV	ACVR2B-AS1 →	+0.779	+0.418	.007	.005	3	3
LSCC	SYPL1P2 →	+0.674	+0.399	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,848 associations by consensus.

CLK2 vs SPAG1 — BRCA

Explore this scatter interactively →