CLK2

Across TCGA patient cohorts, CLK2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLK2-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Tuberin_pT1462. Each is linked with CLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLK2-to-partner and partner-to-CLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CLK2-low versus CLK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK2→partner) and Y-score (partner→CLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.120	-2.321	.017	.034	3	1
UCEC	ERK2 →	+0.205	+3.169	.012	.018	3	1
UCEC	Tuberin_pT1462 →	+0.242	+2.222	.013	.011	3	1
UCEC	Tuberin →	+0.250	+1.700	.029	.044	3	1
UCEC	VHL →	-1.064	-2.906	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.284	+3.179	.040	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

A-Raf_pS299 by CLK2 expression — UCEC

Explore this box plot interactively →