CLK2

Across TCGA cell cohorts, CLK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,041 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CLK2-associated GO terms across cancer lineages are Regulation of double-strand break repair, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with CLK2 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLK2-to-partner and partner-to-CLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by CLK2-low versus CLK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK2→partner) and Y-score (partner→CLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.082	+1.376	<.001	<.001	3	17
OVARY	Heterochromatin formation →	+0.064	+0.612	.001	.004	3	17
STOMACH	Epigenetic regulation of gene expression →	+0.093	+1.145	<.001	<.001	3	17
URINARY_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.118	+1.123	<.001	.001	3	17
PANCREAS	Regulation of RNA splicing →	+0.079	+0.728	<.001	.001	3	17
STOMACH	Positive regulation of double-strand break repair →	+0.117	+1.093	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,041 associations by consensus.

Regulation of double-strand break repair by CLK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →