CLIP2

Across TCGA cell cohorts, CLIP2 mutation is significantly associated with the RNA expression of many other genes, with 456 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLIP2-associated genes across cancer lineages are PROP1, CASP8AP2, and COPS4. Each is linked with CLIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIP2-to-partner and partner-to-CLIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by CLIP2-low versus CLIP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIP2→partner) and Y-score (partner→CLIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.020	+3.289	.001	.009	3	2
LARGE_INTESTINE	CASP8AP2 →	+0.651	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	COPS4 →	+0.810	+2.628	<.001	.002	3	2
LARGE_INTESTINE	USO1 →	+0.490	+2.389	.005	.006	3	2
LARGE_INTESTINE	RAB33B →	+0.642	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ZNF620 →	+0.543	+3.169	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 456 associations by consensus.

PROP1 by CLIP2 expression — BLOOD_Leukemia

Explore this box plot interactively →