CLIC5

Across TCGA pan-cancer cohorts, CLIC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLIC5 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CLIC5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CLIC5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where CLIC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.886	.002	66	view →
LUAD	DFS	Tertile	All	0.820	0.997	<.001	22	view →
HNSC	DFS	Median	IV	0.838	0.576	.007	16	view →
PDAC	OS	Quartile	All	0.715	0.408	.004	11	view →
LSCC	OS	Tertile	All	0.925	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLIC5–CCRCC (OS)

Open the CCRCC breakdown →