CLIC5

Across TCGA patient cohorts, CLIC5 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC5-associated genes across cancer lineages are p27_pT198, Src_pY527, and TIGAR. Each is linked with CLIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC5-to-partner and partner-to-CLIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by CLIC5-low versus CLIC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC5→partner) and Y-score (partner→CLIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.093	+1.906	.030	.016	3	2
UCEC	Src_pY527 →	-0.383	-3.449	.027	.005	3	2
UCEC	TIGAR →	+0.164	+3.321	.007	.009	3	2
UCEC	eIF4E →	+0.231	+3.472	.006	.002	3	1
UCEC	GSK-3_pS9 →	-0.373	-3.459	.021	.005	3	1
UCEC	IGFBP2 →	-0.681	-1.906	.009	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p27_pT198 by CLIC5 expression — UCEC

Explore this box plot interactively →