CLIC5

Across TCGA cell cohorts, CLIC5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLIC5-associated genes across cancer lineages are CFAP97D2, PRH2, and TPPP2. Each is linked with CLIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC5-to-partner and partner-to-CLIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFAP97D2 grouped by CLIC5-low versus CLIC5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC5→partner) and Y-score (partner→CLIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
SKIN	PRH2 →	+0.112	+3.544	.002	.006	3	1
SKIN	TPPP2 →	+0.059	+4.047	<.001	<.001	3	1
SKIN	CDR1 →	+0.239	+4.505	<.001	<.001	3	1
SKIN	TNFRSF18 →	+0.115	+3.307	<.001	.008	3	1
SKIN	GGTLC3 →	+0.054	+2.878	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CFAP97D2 by CLIC5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →