CLIC4

Across TCGA pan-cancer cohorts, CLIC4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated CLIC4 data layer compared with 28 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CLIC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CLIC4 expression acts as an unfavorable survival marker.

THYM, SKCM, and KIRP are the cancer types where CLIC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
SKCM	OS	Median	All	0.230	0.781	.004	18	view →
KIRP	OS	Median	All	0.135	0.703	.002	12	view →
COAD	OS	Median	All	0.111	0.871	<.001	12	view →
LUAD	OS	Median	All	0.277	0.812	.006	9	view →
SARC	OS	Median	All	0.022	0.861	<.001	6	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
BLCA	OS	Median	IV	0.130	0.599	.028	6	view →
LUSC	OS	Median	All	0.196	0.675	.049	6	view →
ESCA	DFS	Median	II,III,IV	0.190	0.525	.032	6	view →
HNSC	OS	Median	All	0.187	0.685	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

CLIC4–THYM (OS)

Open the THYM breakdown →