CLIC4

Across TCGA pan-cancer cohorts, CLIC4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CLIC4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CLIC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLIC4 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where CLIC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLIC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.383	<.001	12	view →
KIRC	All	All	+0.598	<.001	10	view →
KICH	Female	II,III,IV	−3.712	<.001	9	view →
BLCA	Male	All	−1.739	.005	7	view →
LUAD	Female	All	−0.535	<.001	6	view →
LUSC	All	All	−0.482	<.001	3	view →
READ	Female	All	−1.999	.002	2	view →
UCEC	All	All	−1.679	<.001	2	view →
PRAD	All	All	−0.730	<.001	2	view →
CHOL	All	II,III,IV	+0.625	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CLIC4–HNSC

Open the HNSC breakdown →