CLIC4

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CLIC4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,973 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLIC4-associated genes across cancer lineages are LGALS1, GFPT2, and EMILIN1. Each is linked with CLIC4 in more than 8 cancer types. Because this analysis shows association rather than direction, both CLIC4-to-partner and partner-to-CLIC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLIC4 versus LGALS1 in OV, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC4→partner) and Y-score (partner→CLIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVLGALS1 →+1.259+0.553<.001<.00139
OVGFPT2 →+1.550+0.433<.001<.00139
OVEMILIN1 →+1.675+0.477<.001<.00139
OVTAGLN →+1.727+0.519<.001<.00139
OVAEBP1 →+2.150+0.465<.001<.00138
UCECACTA2 →+2.804+0.574<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 13,973 associations by consensus.

CLIC4 vs LGALS1 — OV

Per-sample scatter of CLIC4 vs LGALS1 in OV (Pearson r = 0.41).

Explore this scatter interactively →

Exploration