CLIC4

Across TCGA patient cohorts, CLIC4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC4-associated genes across cancer lineages are eIF4G, MSH2, and CD20. Each is linked with CLIC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC4-to-partner and partner-to-CLIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by CLIC4-low versus CLIC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC4→partner) and Y-score (partner→CLIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.385	+3.169	.013	.018	3	1
UCEC	MSH2 →	-0.251	-2.973	.030	.035	3	1
UCEC	CD20 →	+0.149	+3.189	.023	.010	3	1
UCEC	Cyclin-E2 →	+0.184	+2.321	.029	.035	3	1
UCEC	MEK1 →	+0.538	+2.321	.003	.035	1	2
UCEC	mTOR_pS2448 →	-0.189	-2.321	.011	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4G by CLIC4 expression — UCEC

Explore this box plot interactively →