CLIC4

Across TCGA cell cohorts, CLIC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,145 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CLIC4-associated GO terms across cancer lineages are Vesicle cargo loading, Muscle organ development, and Peptidyl-lysine oxidation. Each is linked with CLIC4 in more than 14 cancer types. Because this analysis shows association rather than direction, both CLIC4-to-partner and partner-to-CLIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle cargo loading grouped by CLIC4-low versus CLIC4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC4→partner) and Y-score (partner→CLIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Vesicle cargo loading →	+0.097	+1.280	<.001	<.001	3	15
CNS	Muscle organ development →	+0.091	+1.072	<.001	<.001	3	13
BREAST	Peptidyl-lysine oxidation →	+1.179	+1.670	<.001	<.001	3	13
LARGE_INTESTINE	Negative regulation of cell cycle G1/S phase transition →	+0.070	+1.412	.001	<.001	3	13
KIDNEY	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.086	+1.585	<.001	<.001	3	12
BREAST	Intracellular transport of virus →	+0.212	+1.856	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,145 associations by consensus.

Vesicle cargo loading by CLIC4 expression — SOFT_TISSUE

Explore this box plot interactively →