CLIC3

Across TCGA patient cohorts, CLIC3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,653 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLIC3-associated genes across cancer lineages are SLPI, LMO7, and MALL. Each is linked with CLIC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLIC3-to-partner and partner-to-CLIC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLIC3 versus SLPI in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC3→partner) and Y-score (partner→CLIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLPI →	+2.501	+0.743	<.001	<.001	3	5
OV	LMO7 →	+0.720	+0.567	<.001	<.001	3	5
HNSC	MALL →	+1.393	+1.034	<.001	<.001	3	5
GBM	DENND2C →	+0.801	+1.528	.003	.007	3	5
HNSC	ALS2CL →	+1.031	+0.915	<.001	<.001	3	5
HNSC	SCEL →	+1.532	+0.795	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,653 associations by consensus.

CLIC3 vs SLPI — BRCA

Explore this scatter interactively →