CLIC3

Across TCGA patient cohorts, CLIC3 mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC3-associated genes across cancer lineages are IGHVII-28-1, IGHD1-26, and RNA5SP292. Each is linked with CLIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC3-to-partner and partner-to-CLIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-28-1 grouped by CLIC3-low versus CLIC3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC3→partner) and Y-score (partner→CLIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	IGHVII-28-1 →	+0.717	+7.977	<.001	.007	3	2
UCEC	IGHD1-26 →	+0.659	+3.069	<.001	.009	3	2
BLCA	RNA5SP292 →	+0.238	+7.640	<.001	.009	3	2
SKCM	OR5H5P →	+0.034	+7.816	<.001	.008	3	1
LGG	PRY2 →	+0.034	+7.977	<.001	.007	3	1
LGG	RNU6-573P →	+0.338	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

IGHVII-28-1 by CLIC3 expression — LGG

Explore this box plot interactively →