CLHC1

Across TCGA cell cohorts, CLHC1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLHC1-associated genes across cancer lineages are SLC35G3, OR6N1, and MYOT. Each is linked with CLHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLHC1-to-partner and partner-to-CLHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35G3 grouped by CLHC1-low versus CLHC1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLHC1→partner) and Y-score (partner→CLHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC35G3 →	+0.016	+6.357	<.001	<.001	3	2
BLOOD_Lymphoma	OR6N1 →	+0.349	+4.867	<.001	.009	3	1
LARGE_INTESTINE	MYOT →	+0.081	+2.008	.001	.008	3	1
LARGE_INTESTINE	ALKBH7 →	+0.401	+2.502	.007	.005	3	1
LARGE_INTESTINE	NES →	-1.336	-3.169	.007	.009	3	1
LARGE_INTESTINE	FGF7 →	+0.126	+3.398	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

SLC35G3 by CLHC1 expression — CNS

Explore this box plot interactively →