CLHC1

Across TCGA pan-cancer cohorts, CLHC1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CLHC1 data layer compared with 7 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CLHC1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CLHC1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and THYM show a favorable association.

BLCA, COAD, and ACC are the cancer types where CLHC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.588	0.317	<.001	86	view →
COAD	OS	Median	All	0.727	0.879	<.001	71	view →
ACC	DFS	Tertile	All	0.347	0.767	<.001	60	view →
LIHC	DFS	Tertile	All	0.421	0.574	<.001	49	view →
KIRC	DFS	Tertile	II,III,IV	0.409	0.624	.002	47	view →
CHOL	OS	Median	II,III,IV	0.285	0.765	.004	41	view →
THYM	DFS	Tertile	All	0.871	0.636	<.001	38	view →
LGG	DFS	Tertile	All	0.762	0.885	<.001	36	view →
UVM	DFS	Tertile	III,IV	0.275	0.860	.004	31	view →
READ	OS	Quartile	II,III,IV	0.796	0.364	.003	28	view →
UCEC	OS	Median	III,IV	0.900	0.755	.003	26	view →
PAAD	OS	Median	II,III,IV	0.613	0.331	.003	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CLHC1–BLCA (OS)

Open the BLCA breakdown →