CLGN

Across TCGA patient cohorts, CLGN mutation is significantly associated with the RNA expression of many other genes, with 2,113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLGN-associated genes across cancer lineages are PGBD4P2, BCL2L2-PABPN1, and MIR4510. Each is linked with CLGN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLGN-to-partner and partner-to-CLGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by CLGN-low versus CLGN-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLGN→partner) and Y-score (partner→CLGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
SKCM	BCL2L2-PABPN1 →	+0.420	+2.227	<.001	.001	3	2
SKCM	MIR4510 →	+0.085	+3.822	<.001	<.001	3	2
SKCM	MIR5585 →	+0.277	+1.876	<.001	.004	3	2
UCEC	PLBD2 →	+0.462	+3.928	<.001	<.001	3	2
UCEC	BAG3 →	+0.619	+3.871	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,113 associations by consensus.

PGBD4P2 by CLGN expression — READ

Explore this box plot interactively →