CLGN

Across TCGA cell cohorts, CLGN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,766 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLGN-associated GO terms across cancer lineages are Regulation of heart rate by cardiac conduction, Endoplasmic reticulum to Golgi vesicle-mediated transport, and Paranodal junction assembly. Each is linked with CLGN in more than 10 cancer types. Because this analysis shows association rather than direction, both CLGN-to-partner and partner-to-CLGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heart rate by cardiac conduction grouped by CLGN-low versus CLGN-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLGN→partner) and Y-score (partner→CLGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of heart rate by cardiac conduction →	-0.246	-2.224	<.001	<.001	3	11
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.085	+1.402	.007	.004	2	11
BLOOD_Leukemia	Paranodal junction assembly →	-0.657	-1.174	<.001	<.001	3	10
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	-0.223	-1.962	<.001	<.001	3	9
STOMACH	Cardiac conduction →	-0.219	-2.046	<.001	<.001	3	9
OESOPHAGUS	Cell communication involved in cardiac conduction →	-0.221	-1.205	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,766 associations by consensus.

Regulation of heart rate by cardiac conduction by CLGN expression — STOMACH

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