CLEC5A

Across TCGA patient cohorts, CLEC5A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CLEC5A-associated genes across cancer lineages are ASNS, Tuberin, and Notch1. Each is linked with CLEC5A in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC5A-to-partner and partner-to-CLEC5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CLEC5A-low versus CLEC5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC5A→partner) and Y-score (partner→CLEC5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.684	+3.000	<.001	.036	3	2
SKCM	Tuberin →	+0.245	+1.678	.048	.022	3	2
UCEC	Notch1 →	+0.246	+3.321	<.001	.010	3	1
UCEC	PDK1_pS241 →	+0.204	+3.000	.023	.036	3	1
UCEC	STAT3_pY705 →	-0.680	-3.321	<.001	.010	3	1
UCEC	VHL →	-0.968	-3.321	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ASNS by CLEC5A expression — UCEC

Explore this box plot interactively →