CLEC5A

Across TCGA pan-cancer cohorts, CLEC5A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CLEC5A data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher CLEC5A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CLEC5A expression acts as an unfavorable survival marker, although some lineages such as DLBC and SKCM show a favorable association.

OV, LGG, and LIHC are the cancer types where CLEC5A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.254	0.370	<.001	70	view →
LGG	DFS	Median	All	0.636	0.839	<.001	54	view →
LIHC	OS	Tertile	All	0.415	0.623	<.001	54	view →
DLBC	DFS	Median	All	0.955	0.604	.002	53	view →
SKCM	OS	Median	II,III,IV	0.396	0.213	<.001	53	view →
KIRP	DFS	Tertile	All	1.000	0.735	.002	45	view →
KICH	OS	Median	All	0.678	1.000	.003	41	view →
LAML	DFS	Tertile	All	0.737	0.456	<.001	36	view →
MESO	OS	Tertile	III,IV	0.407	0.742	.001	31	view →
HNSC	DFS	Median	IV	0.743	0.597	.006	21	view →
SARC	DFS	Quartile	All	0.193	0.433	<.001	16	view →
ACC	OS	Median	II,III,IV	0.756	0.959	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CLEC5A–OV (OS)

Open the OV breakdown →