CLEC4M

Across TCGA patient cohorts, CLEC4M mutation is significantly associated with the RNA expression of many other genes, with 1,441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC4M-associated genes across cancer lineages are ZMYND19, MRPS11, and RPL23AP82. Each is linked with CLEC4M in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC4M-to-partner and partner-to-CLEC4M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMYND19 grouped by CLEC4M-low versus CLEC4M-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4M→partner) and Y-score (partner→CLEC4M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZMYND19 →	+0.456	+2.478	<.001	<.001	3	2
UCEC	MRPS11 →	+0.282	+1.545	.006	.007	3	2
SKCM	RPL23AP82 →	+0.425	+2.178	.003	.008	3	2
UCEC	NDUFA6 →	+0.430	+2.269	<.001	<.001	3	2
UCEC	NF2 →	+0.333	+1.470	.008	.008	3	2
SKCM	WDR5 →	+0.369	+1.768	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,441 associations by consensus.

ZMYND19 by CLEC4M expression — SKCM

Explore this box plot interactively →