CLEC1A

Across TCGA patient cohorts, CLEC1A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC1A-associated genes across cancer lineages are Notch1, C-Raf, and PDCD4. Each is linked with CLEC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC1A-to-partner and partner-to-CLEC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CLEC1A-low versus CLEC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC1A→partner) and Y-score (partner→CLEC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.294	+3.000	<.001	.037	3	2
UCEC	C-Raf →	+0.188	+3.000	.023	.037	3	2
UCEC	PDCD4 →	-0.805	-3.000	.003	.037	3	1
UCEC	eIF4E →	+0.264	+3.000	.030	.037	1	1
UCEC	MEK1 →	+0.572	+3.000	.006	.037	1	1
UCEC	p62 Lck ligand →	+0.671	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by CLEC1A expression — UCEC

Explore this box plot interactively →