CLEC18C

Across TCGA pan-cancer cohorts, CLEC18C RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CLEC18C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLEC18C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLEC18C is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where CLEC18C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLEC18C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.971	<.001	11	view →
KIRP	Male	III,IV	−1.583	<.001	10	view →
KICH	All	II,III,IV	−1.018	<.001	7	view →
BRCA	All	III,IV	+0.018	.012	2	view →
COAD	All	II,III,IV	+0.009	.036	2	view →
LIHC	All	All	+0.009	.027	2	view →
LUSC	All	All	+0.027	.036	1	view →
THCA	Male	II,III,IV	+0.021	.022	1	view →
HNSC	Male	All	+0.010	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CLEC18C–KIRC

Open the KIRC breakdown →