CLEC18B

Across TCGA patient cohorts, CLEC18B mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC18B-associated genes across cancer lineages are MEK1, p62 Lck ligand, and ERK2. Each is linked with CLEC18B in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC18B-to-partner and partner-to-CLEC18B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CLEC18B-low versus CLEC18B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC18B→partner) and Y-score (partner→CLEC18B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.415	+3.000	.049	.037	3	1
UCEC	p62 Lck ligand →	+0.461	+3.000	.014	.037	3	1
UCEC	ERK2 →	+0.283	+3.000	.011	.036	2	1
UCEC	SLC1A5 →	-0.711	-2.992	.003	.036	2	1
UCEC	4E-BP1 →	+0.463	+3.000	.003	.037	1	2
UCEC	Ku80 →	+0.313	+3.013	.022	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by CLEC18B expression — UCEC

Explore this box plot interactively →