CLEC12A-AS1

Across TCGA pan-cancer cohorts, CLEC12A-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CLEC12A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CLEC12A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CLEC12A-AS1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where CLEC12A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLEC12A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.700	<.001	11	view →
KIRC	Male	II,III,IV	+0.095	<.001	11	view →
LUSC	All	All	+0.265	<.001	5	view →
STAD	All	All	+0.046	.014	4	view →
COAD	All	III,IV	−0.034	.009	4	view →
LUAD	Male	All	+0.076	.006	3	view →
BLCA	All	All	+0.072	.038	2	view →
BRCA	Female	All	+0.020	.034	2	view →
THCA	Female	III,IV	−0.016	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CLEC12A-AS1–HNSC

Open the HNSC breakdown →