CLDND2

Across TCGA pan-cancer cohorts, CLDND2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CLDND2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CLDND2 RNA is repressed in tumor relative to normal tissue. In most cancer types CLDND2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and KIRC are the cancer types where CLDND2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLDND2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.079	<.001	10	view →
LIHC	All	II,III,IV	+1.024	<.001	9	view →
KIRC	Female	All	+0.465	.001	7	view →
BRCA	All	II,III,IV	−1.066	<.001	6	view →
LUAD	All	All	−0.343	<.001	6	view →
UCEC	All	All	−0.464	.014	4	view →
COAD	All	II,III,IV	+0.432	.002	4	view →
THCA	Male	III,IV	−0.615	.013	3	view →
CHOL	All	All	+0.787	.002	2	view →
LUSC	Female	All	−0.361	.028	2	view →
PRAD	All	All	−0.290	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CLDND2–KICH

Open the KICH breakdown →