CLDN9

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CLDN9 mutation is significantly associated with the RNA expression of many other genes, with 204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN9-associated genes across cancer lineages are SGTA, FZR1, and DPP9. Each is linked with CLDN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN9-to-partner and partner-to-CLDN9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN9→partner) and Y-score (partner→CLDN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSGTA →+0.420+3.268.006.00832
UCECFZR1 →+0.424+2.595.009.00632
UCECDPP9 →+0.412+3.212<.001.00932
STADTTTY8 →+0.020+4.597<.001.00532
UCECRNU6-147P →+0.261+3.229.001.00132
UCECTRIM77 →+0.060+2.869<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

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