CLDN8

Across TCGA patient cohorts, CLDN8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,040 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CLDN8-associated GO terms across cancer lineages are Peroxisome organization, C21-steroid hormone metabolic process, and Cellular response to indole-3-methanol. Each is linked with CLDN8 in more than 11 cancer types. Because this analysis shows association rather than direction, both CLDN8-to-partner and partner-to-CLDN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peroxisome organization grouped by CLDN8-low versus CLDN8-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN8→partner) and Y-score (partner→CLDN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Peroxisome organization →	+0.035	+1.900	<.001	<.001	3	12
ESCA	C21-steroid hormone metabolic process →	+0.059	+1.638	<.001	<.001	3	12
UCS	Cellular response to indole-3-methanol →	+0.098	+0.806	<.001	<.001	3	12
THYM	Vesicle-mediated transport between endosomal compartments →	+0.040	+1.857	<.001	<.001	3	12
THYM	Positive regulation of macroautophagy →	+0.054	+2.292	<.001	<.001	3	12
SCLC	Vacuole organization →	+0.058	+0.393	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,040 associations by consensus.

Peroxisome organization by CLDN8 expression — THYM

Explore this box plot interactively →