CLDN8

Across TCGA patient cohorts, CLDN8 protein abundance is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CLDN8-associated genes across cancer lineages are SLC7A6, PLAUR, and DDX46. Each is linked with CLDN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN8-to-partner and partner-to-CLDN8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN8 versus SLC7A6 in CCRCC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN8→partner) and Y-score (partner→CLDN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC7A6 →	+0.744	+0.254	.009	.009	2	1
CCRCC	PLAUR →	+1.229	+0.254	.003	.009	2	1
CCRCC	DDX46 →	+0.254	+0.254	.001	.009	2	1
CCRCC	LRP1B →	+0.690	+0.254	.002	.009	2	1
CCRCC	E2F4 →	+0.269	+0.254	.003	.009	2	1
CCRCC	RNU6-425P →	-1.370	-0.254	.004	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CLDN8 vs SLC7A6 — CCRCC

Explore this scatter interactively →