CLDN8

Across TCGA patient cohorts, CLDN8 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN8-associated genes across cancer lineages are EGFR_pY1068, FASN, and ACC1. Each is linked with CLDN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN8-to-partner and partner-to-CLDN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLDN8-low versus CLDN8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN8→partner) and Y-score (partner→CLDN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.210	-2.321	.033	.033	3	1
UCEC	FASN →	+0.399	+2.321	.009	.034	3	1
UCEC	ACC1 →	+0.307	+1.584	.031	.036	3	1
UCEC	INPP4B →	-0.279	-1.807	.028	.025	3	1
UCEC	Ku80 →	+0.249	+1.598	.007	.022	3	1
UCEC	MEK1 →	+0.466	+3.906	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by CLDN8 expression — UCEC

Explore this box plot interactively →