CLDN8

Across TCGA cell cohorts, CLDN8 RNA expression is significantly associated with the go_rna of many other GO terms, with 914 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CLDN8-associated GO terms across cancer lineages are Response to indole-3-methanol, Serotonin secretion, and Inner cell mass cell differentiation. Each is linked with CLDN8 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLDN8-to-partner and partner-to-CLDN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by CLDN8-low versus CLDN8-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN8→partner) and Y-score (partner→CLDN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Response to indole-3-methanol →	+0.134	+0.524	<.001	.005	3	6
LUNG_NSCLC_LUAD	Serotonin secretion →	+1.055	+0.667	<.001	.003	3	5
LUNG_NSCLC_LUAD	Inner cell mass cell differentiation →	+0.974	+1.034	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Negative regulation of potassium ion transmembrane transporter activity →	+0.718	+0.713	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Negative regulation of voltage-gated potassium channel activity →	+0.718	+0.713	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Serotonin production involved in inflammatory response →	+1.055	+0.667	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

Response to indole-3-methanol by CLDN8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →