CLDN8

Across TCGA cell cohorts, CLDN8 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CLDN8-associated genes across cancer lineages are RFPL3, MMP20, and SSX5. Each is linked with CLDN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN8-to-partner and partner-to-CLDN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by CLDN8-low versus CLDN8-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN8→partner) and Y-score (partner→CLDN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RFPL3 →	+0.047	+3.954	.007	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	MMP20 →	+0.116	+3.386	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	SSX5 →	+0.019	+2.777	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	SERPINA11 →	+0.096	+4.125	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	KRTAP21-2 →	+0.199	+3.239	.001	.002	3	2
LUNG_SCLC	PRAMEF19 →	+0.013	+5.029	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RFPL3 by CLDN8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →