Across TCGA patient cohorts, CLDN6 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN6-associated genes across cancer lineages are INPP4B, VHL, and Bak. Each is linked with CLDN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN6-to-partner and partner-to-CLDN6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN6→partner) and Y-score (partner→CLDN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.397	-2.986	.033	.037	3	1
UCEC	VHL →	-1.351	-3.000	<.001	.036	3	1
UCEC	Bak →	+0.314	+3.000	.030	.037	3	1
UCEC	c-Met_pY1235 →	+0.115	+2.817	.007	.036	3	1
UCEC	BRCA2 →	-0.180	-2.992	.014	.036	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

CLDN6 survival (RNA) · tumor vs normal (RNA) · all CLDN6 data types