Across TCGA patient cohorts, CLDN5 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN5-associated genes across cancer lineages are RNU6ATAC22P, VDAC1P5, and RN7SL726P. Each is linked with CLDN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN5-to-partner and partner-to-CLDN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN5→partner) and Y-score (partner→CLDN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6ATAC22P →	+0.662	+3.845	<.001	<.001	3	2
UCEC	VDAC1P5 →	+0.124	+3.140	.003	.004	3	1
UCEC	RN7SL726P →	+0.221	+3.488	<.001	.002	3	1
UCEC	ELMO2P1 →	+0.288	+3.432	<.001	.001	3	1
UCEC	RN7SL820P →	+0.251	+3.246	<.001	.008	3	1
COAD	MTND5P27 →	+0.143	+5.917	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Exploration

CLDN5 survival (RNA) · tumor vs normal (RNA) · all CLDN5 data types