voltage dependent anion channel 1 pseudogene 5Genealiases: VDAC3 · VDAC5P
Q-omics provides the consensus-scored VDAC1P5 profile across patient tissues and cancer cell-line models. VDAC1P5 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in TGCT. Among the 18 cancer types available for tumor–normal comparison, VDAC1P5 is differentially expressed in 8, with the highest sampling consensus in BRCA. Additionally, VDAC1P5 RNA expression shows 6,038 significant protein co-abundance associations, with the highest sampling consensus in OV. Together, these results highlight TGCT, BRCA, and OV as cancer lineages where VDAC1P5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for VDAC1P5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes VDAC1P5 survival associations across molecular data types. VDAC1P5 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible VDAC1P5 RNA expression–survival associations across cancer types. High VDAC1P5 expression shows unfavorable associations in TGCT, UCEC, MESO, STAD and LIHC, but favorable associations in CESC. The TGCT Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .014). Together, the overview and detailed table identify TGCT as the clearest survival context for VDAC1P5 RNA expression.
This table summarizes VDAC1P5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for VDAC1P5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. VDAC1P5 shows higher tumor expression in BRCA, COAD, BLCA, HNSC, KICH and LUSC. The BRCA box plot shows higher VDAC1P5 RNA expression in tumor versus normal tissue (log2 FC = +0.041, t-test p < 0.001).
This table shows molecular features associated with VDAC1P5 in patient tissues and cancer cell lines. In patient samples, VDAC1P5 shows the broadest associations at the RNA and protein expression levels, with OV recurring as the lineage with the largest associated feature set.
