CLDN3

Across TCGA patient cohorts, CLDN3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,669 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CLDN3-associated genes across cancer lineages are ABHD11, PMP22, and HLX. Each is linked with CLDN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLDN3-to-partner and partner-to-CLDN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN3 versus ABHD11 in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN3→partner) and Y-score (partner→CLDN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABHD11 →	+0.615	+0.686	<.001	<.001	3	5
CCRCC	PMP22 →	-0.573	-0.406	<.001	.005	3	5
CCRCC	HLX →	-0.488	-0.525	<.001	.003	3	5
CCRCC	FAP →	-0.994	-0.658	<.001	<.001	3	5
HNSC	TSPAN12 →	+1.240	+0.987	<.001	.006	3	5
LSCC	FRMD6 →	-1.143	-1.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,669 associations by consensus.

CLDN3 vs ABHD11 — BRCA

Explore this scatter interactively →