CLDN3

Across TCGA pan-cancer cohorts, CLDN3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CLDN3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CLDN3 RNA is repressed in tumor relative to normal tissue. In most cancer types CLDN3 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LUAD, and KIRC are the cancer types where CLDN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLDN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−5.247	<.001	11	view →
LUAD	All	III,IV	+2.018	<.001	11	view →
KIRC	Male	III,IV	−1.262	<.001	11	view →
STAD	Male	II,III,IV	+4.733	<.001	9	view →
LUSC	Female	II,III,IV	−2.988	<.001	7	view →
UCEC	All	All	+3.341	<.001	6	view →
BRCA	All	All	+1.286	<.001	6	view →
ESCA	All	All	+3.191	.030	2	view →
CHOL	Male	All	+2.489	<.001	2	view →
PRAD	All	All	+0.921	<.001	2	view →
READ	All	III,IV	−0.625	.047	2	view →
COAD	Female	All	+0.519	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CLDN3–KICH

Open the KICH breakdown →