CLDN3

Across TCGA cell cohorts, CLDN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,404 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CLDN3-associated GO terms across cancer lineages are Regulation of transepithelial transport, Establishment of epithelial cell apical/basal polarity, and Sperm motility. Each is linked with CLDN3 in more than 11 cancer types. Because this analysis shows association rather than direction, both CLDN3-to-partner and partner-to-CLDN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transepithelial transport grouped by CLDN3-low versus CLDN3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN3→partner) and Y-score (partner→CLDN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of transepithelial transport →	-0.141	-2.434	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.252	-3.564	.001	.002	3	11
LUNG_SCLC	Sperm motility →	-0.101	-3.620	.003	<.001	3	10
LUNG_SCLC	Cilium or flagellum-dependent cell motility →	-0.079	-3.301	.005	<.001	3	10
LUNG_SCLC	Flagellated sperm motility →	-0.101	-3.620	.003	<.001	3	10
LUNG_SCLC	Cilium-dependent cell motility →	-0.079	-3.301	.005	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,404 associations by consensus.

Regulation of transepithelial transport by CLDN3 expression — LIVER

Explore this box plot interactively →