CLDN22

Across TCGA patient cohorts, CLDN22 RNA expression is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible CLDN22-associated genes across cancer lineages are POU3F4, TSSK4, and ESR1. Each is linked with CLDN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN22-to-partner and partner-to-CLDN22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN22 versus POU3F4 in SCLC, with a Pearson correlation of 0.86.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN22→partner) and Y-score (partner→CLDN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	POU3F4 →	+0.778	+0.570	<.001	.004	3	1
SCLC	TSSK4 →	+1.306	+0.656	.002	.001	3	1
SCLC	ESR1 →	+1.005	+0.302	.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CLDN22 vs POU3F4 — SCLC

Explore this scatter interactively →