CLDN18

Across TCGA patient cohorts, CLDN18 protein abundance is significantly associated with the protein abundance of many other proteins, with 8,061 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLDN18-associated proteins across cancer lineages are CLDN18_S228, CLDN18_S233, and CAPN5. Each is linked with CLDN18 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLDN18-to-partner and partner-to-CLDN18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN18 versus CLDN18_S228 in PDAC, with a Pearson correlation of 0.91.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN18→partner) and Y-score (partner→CLDN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CLDN18_S228 →	+2.593	+2.849	<.001	<.001	3	4
PDAC	CLDN18_S233 →	+3.010	+3.063	<.001	<.001	3	4
PDAC	CAPN5 →	+0.652	+1.590	<.001	<.001	3	3
PDAC	CAPN9 →	+0.971	+1.853	<.001	<.001	3	3
LSCC	RFX3_S155 →	+0.525	+0.670	.002	<.001	3	3
LUAD	SPTAN1 →	+0.310	+1.173	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,061 associations by consensus.

CLDN18 vs CLDN18_S228 — PDAC

Explore this scatter interactively →