CLDN18

Across TCGA patient cohorts, CLDN18 mutation is significantly associated with the RNA expression of many other genes, with 2,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN18-associated genes across cancer lineages are KRTAP19-5, CDKN3, and BCCIP. Each is linked with CLDN18 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLDN18-to-partner and partner-to-CLDN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-5 grouped by CLDN18-low versus CLDN18-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN18→partner) and Y-score (partner→CLDN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KRTAP19-5 →	+0.170	+4.540	<.001	.009	3	3
SKCM	CDKN3 →	+0.857	+3.208	<.001	.009	3	3
SKCM	BCCIP →	+0.605	+3.182	.003	.009	3	3
UCEC	CDCA5 →	+0.677	+3.584	.001	.002	3	3
SKCM	KIFBP →	+0.520	+3.207	.009	.009	3	3
UCEC	TRMU →	+0.407	+2.000	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,226 associations by consensus.

KRTAP19-5 by CLDN18 expression — BRCA

Explore this box plot interactively →